Encountered a problem @ program startup

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Installed no problem, upon actually trying to run the game I get the generic "Colony Defense has encountered a problem and needs to close..." error. Is there any common cause of this?

Windows XP Pro SP3 Build 2600
Radeon 3650HD Pro @ 512MB
AMD64 3500+
3GB RAM

AppName: colonydefense.exe AppVer: 1.0.5.1 AppStamp:4b80c057
ModName: kernel32.dll ModVer: 5.1.2600.5781 ModStamp:49c4f2bb
fDebug: 0 Offset: 00012afb

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